Table 2.
Exploratory Analyses in the Monotherapy Study
| Results at Day 43 | Placebo (n = 6) | IONIS-AGT-LRx (n = 15) |
|---|---|---|
| Mean absolute change in SBP (mm Hg) | −2 (−19 to 16) | −8 (−17 to 2) |
| Median (quartile 1 to quartile 3) | 0 (−4 to 3) | −12 (−23 to 2) |
| Mean absolute change in DBP (mm Hg) | 4 (−4 to 12) | −1 (−8 to 5) |
| Median (quartile 1 to quartile 3) | 4 (−3 to 6) | −2 (−6 to 4) |
| Patients with ≥5 mm Hg reduction in SBP | 1 (17) | 8 (53) |
| Patients with ≥10 mm Hg reduction in SBP | 1 (17) | 8 (53) |
| Patients with ≥15 mm Hg reduction in SBP | 1 (17) | 5 (33) |
| Patients with ≥5 mm Hg reduction in DBP | 0 (0) | 4 (27) |
| Patients with ≥10 mm Hg reduction in DBP | 0 (0) | 3 (20) |
| Patients with ≥15 mm Hg reduction in DBP | 0 (0) | 3 (20) |
| Patients reaching SBP ≤140 mm Hg | 3 (50) | 10 (67) |
| Patients reaching DBP ≤90 mm Hg | 3 (50) | 11 (73) |
| Mean change in angiotensin II (ng/dl) | 1 ± 5 | 1 ± 8 |
| Mean change in aldosterone (ng/dl) | 0.1 ± 4.2 | 0.0 ± 3.0 |
| Mean change in renin mass (pg/ml) | −1.9 ± 4.2 | 15.7 ± 33.8 |
| Mean change in plasma renin activity (ng/ml/h) | 0.66 ± 2.01 | −0.11 ± 1.74 |
Values are mean (95% confidence interval), n (%), or n (%), or mean ± SD unless otherwise indicated.
Blood pressure results occurred after antihypertensive medications were reinitiated and were removed from this analysis.
Abbreviations as in Table 1.