Table 4.
Exploratory Analyses in the Add-On Study
| Results at Day 57 | Placebo (n = 8) | IONIS-AGT-LRx (n = 16) |
|---|---|---|
| Mean absolute change in SBP (mm Hg) | −5 (−13 to 4) | −12 (−21 to −4) |
| Median (quartile 1 to quartile 3) | −5 (−8 to 0) | −10 (−19 to −2) |
| Mean absolute change in DBP (mm Hg) | 1 (−7 to 9) | −6 (−11 to −1) |
| Median (quartile 1 to quartile 3) | −1 (−8 to 10) | −7 (−9 to 2) |
| Patients with ≥5 mm Hg reduction in SBP | 5 (63) | 11 (69) |
| Patients with ≥10 mm Hg reduction in SBP | 1 (13) | 8 (50) |
| Patients with ≥15 mm Hg reduction in SBP | 1 (13) | 7 (44) |
| Patients with ≥5 mm Hg reduction in DBP | 3 (38) | 10 (63) |
| Mean change in angiotensin II (ng/dl) | 2 ± 10 | −4 ± 19) |
| Mean change in aldosterone (ng/dl) | 0.2 ± 2.9 | −0.8 ± 4.7 |
| Mean change in renin mass (pg/ml) | 16.9 ± 41.7 | 71.9 ± 248.3 |
| Mean change in plasma renin activity (ng/ml/h) | −0.2 ± 0.86 | −1.53 ± 3.76 |
| Patients with ≥10 mm Hg reduction in DBP | 1 (13) | 3 (19) |
| Patients with ≥15 mm Hg reduction in DBP | 0 (0) | 2 (13) |
| Patients reaching SBP ≤140 mm Hg | 2 (25) | 8 (50) |
| Patients reaching DBP ≤80 mm Hg | 1 (13) | 9 (56) |
Values are mean (95% confidence interval), n (%), or mean ± SD unless otherwise indicated.
Abbreviations as in Table 1.