Fig. 7.

Evolutionary and structure-based regularization biases variant selection towards sequences with desirable properties. Shown are sequence logos for the best performing variant selection method along with their unregularized counterpart. All four residues are shown with the GB1 protein (Left), whereas the positions that correspond to variants with the top five true activity/binding affinity scores are shown for BRCA1 (Middle) and Spike (Right). Highlighted residues denote notable distinctions between the regularized and unregularized sequence selections