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Comparison of the genomic alterations associated with different progression patterns. For comparison, 5 patients with PR and 693 TMB- and histology-matched lung cancer samples (Control) from an internal database were selected as controls. The Y-axis represents the mutation frequency of each gene in each group. ***, P<0.001; **, P<0.01; *, P<0.05. FP, fast progression; HPD, hyperprogressive disease; ED, early death; PR, partial response.
