Table 2. Probable risk factors of corneal changes in young and elderly patients.
| Variables | Young patients (n=91)a | Elderly patients (n=92)b | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariate | Multivariate | Univariate | Multivariate | ||||||||
| OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | ||||
| Gender | |||||||||||
| Male | Reference | Reference | Reference | ||||||||
| Female | 4.52 (1.99–10.2) | <0.001 | 0.29 (0.08–1.07) | 0.064 | 0.98 (0.41–2.35) | 0.969 | |||||
| Age | 0.95 (0.89–1.00) | 0.051 | 0.93 (0.86–1.01) | 0.097 | 1.02 (0.98–1.07) | 0.320 | |||||
| Total Demodex | 1.03 (0.97,1.09) | 0.317 | – | – | 0.98 (0.93–1.04) | 0.501 | |||||
| D. brevis % | 5.67 (1.27–25.2) | 0.023 | 22.6 (2.15–236) | 0.009 | 1.98 (0.31–12.6) | 0.472 | |||||
| BUT | 0.95 (0.87–1.03) | 0.227 | – | – | 0.97 (0.89–1.05) | 0.385 | |||||
| TMH | 0.11 (0.01–2.23) | 0.150 | 1.74 (0.04–77.3) | 0.774 | 0.38 (0.01–10.4) | 0.565 | |||||
| Lid margin abnormalities | 3.27 (2.06–5.20) | <0.001 | 3.00 (1.44–6.27) | 0.003 | 1.15 (0.76–1.75) | 0.513 | |||||
| Meiboscore | |||||||||||
| Normal-Mild | Reference | Reference | Reference | Reference | |||||||
| Moderate | 8.17 (2.60–25.7) | <0.001 | 3.44 (0.80–14.8) | 0.096 | 0.93 (0.36–2.38) | 0.873 | 0.93 (0.36–2.38) | 0.873 | |||
| Severe | 62.7 (16.8–233) | <0.001 | 18.9 (3.61–98.6) | 0.001 | 4.81 (1.26–18.3) | 0.022 | 4.81 (1.26–18.3) | 0.022 | |||
| Eyelash disorders | 2.07 (0.95,4.5) | 0.069 | 0.88 (0.28–2.77) | 0.823 | 1.65 (0.65–4.19) | 0.289 | |||||
Variables which P<0.15 were included in the multivariate ordinal logistic regression analysis. a, Ordinal logistic regression; b, binary logistic regression. CI, confidence interval; OR, odds ratio; BUT, tear break-up time; TMH, tear meniscus height. D. brevis, Demodex brevis; D. brevis %, D. brevis/Total Demodex.