Table 1. Univariate analysis of characteristics and oral biomarkers of recruited patients between HC and CRC group.
| Clinical and oral variables | HC (n=95) | CRC (n=142) | P value |
|---|---|---|---|
| Age, mean (SD) | 51.16 (10.75) | 65.07 (10.27) | <0.001*** |
| Male, n (%) | 42 (44.21) | 84 (59.15) | 0.024* |
| BMI, mean (SD) | 23.06 (2.90) | 23.46 (3.55) | 0.324 |
| Dental caries, n (%) | 33 (35.87) | 69 (49.64) | 0.039* |
| OHI median, (IQR) | 1 [1–2] | 2 [1–2] | <0.001*** |
| Comorbidities, n (%) | |||
| Hypertension | 19 (20.00) | 57 (40.14) | 0.001*** |
| Type 2 diabetes | 3 (3.16) | 21 (14.79) | 0.004** |
| Current smoking status, n (%) | 12 (12.63) | 33 (23.24) | 0.041* |
| Current alcohol use, n (%) | 21 (22.11) | 31 (21.83) | 0.96 |
| Biomarkers | |||
| Fn, median (IQR) | 10.125 (9.1584–11.4306) | 9.91 (8.799–11.216) | 0.527 |
| Pg, median (IQR) | 10.103 (8.2519–13.7194) | 8.1999 (6.88–11.6946) | 0.001*** |
| Dd, mean (SD) | 21.4573 (3.28832) | 19.6226 (3.64364) | <0.001*** |
| Pm, median (IQR) | 16.453 (10.55–21.06) | 17.07 (11.546–21.029) | 0.796 |
*, P≤0.05; **, P≤0.01; ***, P≤0.001. HC, healthy control; CRC, colorectal cancer; SD, standard deviation; IQR, interquartile range; BMI, body mass index; OHI, oral hygiene index; Fn, Fusobacterium nucleatum; Pg, Porphyromonas gingivalis; Dd, Desulfovibrio desulfuricans; Pm, Prevotella melanogenica.