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. 2021 May;9(9):761. doi: 10.21037/atm-19-4511

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2021 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Overexpressed CYR61 cannot increase migration and invasion in 5637 cells. Compared with blank control group (5637-pcdb), no difference was observed between overexpressed CYR61 group (5637-CYR61). (A) Migration through transwell chamber migration assay (P<0.05); scale bars: 120 µm. (B) Wound closure in scratch wounding migration assay (100×). Photographs were taken at 36 h. (C) Expression of MMP-2 (P=0.923) and NRP-1 (P=0.579). CYR61, cysteine-rich angiogenic inducer 61; MMP-2, matrix metalloproteinase-2; NRP-1, neuropilin-1.