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. 2021 May;9(9):761. doi: 10.21037/atm-19-4511

Figure 5.

Figure 5

Overexpressed CYR61 increased migration and invasion in UMUC-3 cells. UM-UC-3 -pcdb: UM-UC-3 cells transfected with the pcDNA3.1 blank plasmid server as blank control group; UM-UC-3-CYR61: over-expression of CYR61 in UMUC-3 cells. (A) Migration though transwell chamber migration assay (P<0.001), scale bars: 120 µm. (B) Wound closure in scratch wounding migration assay (100×). Photographs were taken at 24 h. (C) Upregulated expression of MMP-2 (P=0.021) and NRP-1 (P=0.033). CYR61, cysteine-rich angiogenic inducer 61; MMP-2, matrix metalloproteinase-2; NRP-1, neuropilin-1.