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. 2021 May;9(9):768. doi: 10.21037/atm-20-6797

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2021 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Confocal Raman microspectroscopy and mechanical compression of the subchondral bone (SB). (A) Changes in the mineral-to-collagen ratio of the SB among three groups. The mineral-to-collagen ratio was significantly lower in the diabetes-osteoarthritis (DM-OA) group than the osteoarthritis (OA) group and sham group at 8 and 12 weeks. (B) Fracture load of SB’s compression testing for the three groups at 4, 8, and 12 weeks postoperatively. Graph showing that the fracture load of SB trabecular bone in the DM-OA group was continuously diminished compared to that of the OA and sham groups. The data were expressed as the mean ± SD and were compared using ANOVA and the Student-Newman-Keuls post-hoc test between the groups. *, P<0.05 was considered significant.