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. 2021 May;9(9):768. doi: 10.21037/atm-20-6797

Figure 2.

Figure 2

Induction of diabetes and physiological parameters in experimental animals. (A) After the injection of streptozotocin (STZ), the mean level of blood glucose was greater in the diabetes-osteoarthritis (DM-OA) group compared to the osteoarthritis (OA) and sham groups. *, P<0.05. (B) HbA1c level was also significantly greater in the DM-OA group than OA and sham groups. *, P<0.05. (C) The intraperitoneal glucose tolerance tests (IPGTTs) revealed a significant reduction in glycemic control in the DM-OA group. The area under the curve (AUC) was significantly greater in the DM-OA group. *, P<0.05. (D) Histological study of the pancreas of the DM-OA group indicated a dramatic reduction in islets’ size and cellularity. HE stained sections. (D1: DM-OA group; D2: OA group; D3 sham group, scale bar: 100 µm). The data are expressed as the mean ± SD and were compared using ANOVA and the Student-Newman-Keuls post-hoc test between the groups. *, P<0.05 was considered significant.