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. 2021 May;9(9):768. doi: 10.21037/atm-20-6797

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2021 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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mRNA expression of regulators for bone metabolism in the tibias of mice in the diabetes-osteoarthritis (DM-OA) group, osteoarthritis (OA) group, and sham group at 12 weeks postoperatively. The quantitative results for real-time polymerase chain reaction (RT-PCR). The data are expressed as the mean ± SD and were compared using ANOVA and the Student-Newman-Keuls post-hoc test between the groups. *, P<0.05 was considered significant. OPG, osteoprotegerin; RANKL, receptor activator of nuclear factor kappa-B ligand; COL-I, collagen type I; RUNX-2, Runt-related transcription factor 2; OCN, osteocalcin; SOST, sclerostin.