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. 2021 May;9(9):768. doi: 10.21037/atm-20-6797

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2021 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Cartilage degeneration during diabetes mellitus and osteoarthritis (OA) progression (safranin-O/fast green staining). Histology images of the knee joint from the diabetes-osteoarthritis (DM-OA) group (A), OA group (B), and sham group (C) at each time point of sacrifice (4, 8, and 12 weeks postoperatively). Grading of histological sections revealed more serious deterioration of OA’s articular cartilage and progression in the DM-OA group compared to the OA and sham groups. Specifically, we observed focal loss of safranin-O staining, indicating decreased proteoglycan concentration, fissuring of articular cartilage, frequent loss and the flattened elongated chondrocytes, cell death in the articular cartilage, and atrophy of articular chondrocytes.