Table 3. Univariate and multivariate analysis of predictors of 3-month mortality.
| OR | 95% CI | P value | |
|---|---|---|---|
| Univariate analysis of predicting 3-month mortality | |||
| Before AE-FIP | |||
| %FVC (L) | 0.94 | 0.88–1.01 | 0.09 |
| %DLco (%) | 0.93 | 0.86–1.01 | 0.10 |
| ILD-GAP score | 2.02 | 0.99–4.12 | 0.06 |
| At the onset of AE-FIP | |||
| Age, yrs | 0.96 | 0.88–1.05 | 0.37 |
| P/F ratio | 1.00 | 0.99–1.01 | 0.62 |
| CRP (mg/dL) | 1.18 | 1.02–1.36 | 0.03* |
| LDH (IU/L) | 1.00 | 1.00–1.01 | 0.34 |
| BNP (pg/mL) | 1.00 | 0.99–1.00 | 0.63 |
| KL-6 (U/mL) | 1.00 | 0.99–1.00 | 0.53 |
| SP-D (ng/mL) | 1.00 | 1.00–1.01 | 0.03* |
| D-dimer (μg/mL) | 0.98 | 0.92–1.04 | 0.53 |
| HMGB-1 (ng/mL) | 1.02 | 0.98–1.06 | 0.35 |
| Fibrosis score | 1.61 | 0.61–4.24 | 0.34 |
| GGO score | 1.38 | 0.67–2.85 | 0.38 |
| M-PN, day 0 (ng/mL) | 0.99 | 0.88–1.12 | 0.91 |
| Diffuse pattern | 0.89 | 0.20–3.93 | 0.88 |
| M-PN, day 7 (ng/mL) | 4.40 | 0.77–25.15 | 0.10 |
| ΔM-PN ≥−2.7 (ng/mL) | 18.0 | 1.63–198.5 | 0.018* |
| APACHE II score | 1.08 | 0.92–1.26 | 0.35 |
| rhTM use (25 case) | 0.40 | 0.10–1.64 | 0.21 |
| Multivariate analysis of predictors of 3-month mortality (forced entry) | |||
| Serum ΔM-PN ≥−2.7 (ng/mL) | 12.4 | 0.82–187.9 | 0.069 |
| CRP (mg/dL) | 1.27 | 0.90–1.80 | 0.18 |
| SP-D (ng/mL) | 1.00 | 1.00–1.01 | 0.30 |
*P≤0.05. %FVC, %forced vital capacity; %DLco, diffusing capacity for carbon monoxide; ILD-GAP; P/F ratio, PaO2/FiO2 ratio; CRP, C-reactive protein; LDH, lactate dehydrogenase; HMGB-1, high mobility group box-1; BNP, brain natriuretic peptide; SP-D, surfactant protein-D; M-PN, monomeric periostin.