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. 2021 Jun 26;13(6):594–604. doi: 10.4252/wjsc.v13.i6.594

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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Model of increased proliferation in aging hematopoietic stem cells. Aged hematopoietic stem cells (HSC) have a reduced productive potential and generate a fraction of ineffective (gray) progenitor cells, thus producing a reduced number of blood cells. This reduced production of blood cells triggers a stimulus to generate more blood cells, which increases the proliferation rate of the hematopoietic compartment. Increased proliferation is accompanied by telomere shortening, which, in turn, makes HSC even more aged. In this way, the absolute number of HSC increases, but the fraction of ineffective HSC also increases. HSC: Hematopoietic stem cells; PC: Progenitor cells; BC: Blood cells.