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. 2021 Jun 30;9(1):e002311. doi: 10.1136/bmjdrc-2021-002311

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Adjusted HR (95% CI) for ESKD by percentage changes in UACR (A) and annual changes in eGFR (B) over 2 years. Adjusted for sex, age, history of cardiovascular disease, and baseline covariates including HbA1c, systolic blood pressure, log-transformed UACR, and eGFR, and stratified with institution. Event rates per 1000 patient years in each category are shown above the plots. eGFR, estimated glomerular filtration rate; ESKD, end-stage kidney disease; HbA1c, glycated hemoglobin; UACR, urine albumin to creatinine ratio.