Table 4.

Adherence composite scores based on TFV and TFVdp concentrations, with doses estimated/interval

Score	TFV in plasma	TFVdp in ULPC	Estimates doses per interval
0	None detectable	<10 000 fmol/mL	Low number or no doses in the interval
1	Detectable	<10 000 fmol/mL	A few doses in the entire interval
2	Any level	10 000–100 000 fmol/mL	1–2 doses/week
3	<10 ng/mL	>100 000 fmol/mL	Several doses early in the interval, followed by a stop in the 1–2 weeks leading up to sampling visit
4	10 ng/mL or higher	100 000–1 000 000 fmol/mL	4–5 doses/week
5	10 ng/mL or higher	>1 000 000 fmol/mL	Approximately daily dosing

Adapted from Corneli et al.³⁸

TFV, tenofovir; TFVdp, tenofovir diphosphate; ULPC, upper layer packed cells.