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. 2021 Jun 30;9(6):e002426. doi: 10.1136/jitc-2021-002426

Figure 2.

Figure 2

Tc1 cells, but not Tc17-1 cells, prolonged the survival of glioma-bearing mice in vivo. C57BL/6 mice bearing intracranial GL261-Quad glioma received temozolomide (TMZ) on day 9, followed by a single IV infusion of Tc1 or Tc17-1 cells on day 10 after tumor inoculation. (A) Kaplan-Meier survival curve (n=10 per group). Data are pooled from two independent experiments. P=0.0180; log-rank test. (B, C) Representative flow cytometry data showing the frequency of IFN-γ- and IL-17-producing cells (B) and cytotoxic activity against GL261 cells loaded with or without hgp10025-33 peptide (C) in Tc1 and Tc17-1 cells isolated at 7 days after adoptive transfer. Data are representative of two independent experiments and presented as mean±SD. *P<0.05; unpaired two-tailed Student’s t-test. IL-17, interleukin 17; IV, intravenously.