Figure 4.

Expression coordination of genes in gene networks. The expression co variance of genes in networks is regulated by the temporal nature of action potential firing patterns. Gene pairs may show a positive correlation linkage, be negatively correlated or expression variance may be uncorrelated. This analytical approach shows that action potential firing of different patterns modifies how gene networks are coordinately regulated, even though the dynamic stimulation of neuronal firing may not change the level of gene expression to statistically significant levels.