Figure 5.

Neuronal morphology and gene expression. Action potential firing patterns regulate Ca²⁺ signaling in neurons and nuclear events such as chromatin dynamics and transcription. Messenger RNAs and proteins are transported to distal sites in response to temporal intracellular signaling. Signaling from distal sites to the nucleus allows for further modulation of genomic events. Local protein synthesis in axons and at synapses in response to discrete Ca²⁺ signaling allows for rapid modification of information flow throughout sites remote from the cell body and nuclear events.