Skip to main content
. 2021 Jun 30;9(6):e001649. doi: 10.1136/jitc-2020-001649

Figure 2.

Figure 2

Expression of putative prostate antigens is restricted to the prostate in both mouse and humans. (A) Relative expression of androgen-responsive genes, as well as Tarp and Steap1, across normal murine tissues. Boxplots of Log10 (TPM) normalized gene expression in prostate (n=1), brain (n=9), colon (n=1), liver (n=10), lung (n=9), skin (n=2), kidney (n=7), and salivary gland (n=1) from RIKEN FANTOM5 are shown, and genes are ordered by decreasing expression in murine prostate. (B) IF images of selected markers in adjacent sections from indicated mouse tissues—the prostate lobes shown are dorsal prostate lobes for Tgm4 and lateral prostate lobes for Msmb. Scale bars indicate 50 µm. (C) Relative expression of androgen-responsive genes, as well as TARP and STEAP1, across normal human tissues. Boxplots of Log10 (TPM) normalized gene expression in prostate (n=152), brain (n=1671), colon (n=507), liver (n=175), lung (n=427), skin (n=1203), kidney (n=45), and salivary gland (n=97) from GTEx are shown. Wilcoxon test was used for statistical analysis between TGM4 and each indicated gene; p values are displayed. GTEx, Genotype-Tissue Expression; IF, Immunofluorescence; TGM4, Transglutaminase 4.