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. Author manuscript; available in PMC: 2021 Jul 1.
Published in final edited form as: Antiviral Res. 2016 Nov 30;138:40–46. doi: 10.1016/j.antiviral.2016.11.027

Fig. 1.

Fig. 1.

A novel class of Mcl-1 inhibitor induces death of HCMV-infected monocytes. HCMV-infected monocytes or EBV-infected Akata cells were treated with 30 μM of C10 or MIM1. After 24 hours of treatment with inhibitor, cell viability was measured by a Trypan blue exclusion assay. Shown is the mean of 3-4 independent experiments from different blood donors. Differences between experimental groups were evaluated by one-way analysis of variance (ANOVA) with pair-wise multiple comparison procedures. Asterisk (*) represents a P value of <0.05. (B) Monocytes were infected with HCMV at an MOI of 5. Following a 24 h incubation period, infected monocytes were treated with increasing concentrations of C10 for an additional 24 h. Pro-caspase 3 was then detected by immunoblotting and membranes reprobed for β-actin as a loading control. Results are representative of 3 independent experiments from different blood donors.