FIGURE 3.

Coagulation factor VIII (FVIII) dosing based on body weight and ideal body weight in a normal weight, overweight and obese patient. The 3 examples were obtained by selecting typical patients from each body mass index (BMI) category; normal weight (BMI <25 kg m⁻²), overweight (BMI 25–30 kg m⁻²) and obese (BMI >30 kg m⁻²) patient. The lines from the plot depict the individual predicted FVIII levels after a simulated single‐dose of 50 IU kg⁻¹ (upper panels). In the lower panels, a simulated loading‐dose was administered of 50 IU kg⁻¹ followed by twice daily dosing of 25 IU kg⁻¹ to treat a life‐threatening bleed. The individual FVIII levels were estimated using the individual pharmacokinetic (PK) parameters from the corresponding example patients