FIGURE 4.
Dosing based on ideal body weight results in adequate coagulation factor VIII (FVIII) peak and trough levels when treating a life‐threatening bleed. The FVIII peak levels (upper panels) were obtained 5 minutes after the simulated loading‐dose of 50 IU kg−1, which was followed by twice daily dosing of 25 IU kg−1 to treat a life‐threatening bleed. The trough FVIII levels (lower panels) were obtained immediately before the sixth dose, which corresponded with 72 hours after administration of the loading‐dose. The individual FVIII levels were simulated using the individual pharmacokinetic (PK) parameters from each included real‐life patient of the studied population. The blue bar depicts the median FVIII level. To enhance the visibility for the number of FVIII levels in each category, the FVIII levels were scattered horizontally