TABLE 2.

Estimated population pharmacokinetic parameters for structural model and final model

	Structural model			Final model
	Estimate	RSE (%)	Shr. [%]	Estimate	RSE (%)	Shr. [%]
Structural model
Clearance (CL; mL h−1)	242	(6)		236	(5)
Volume of central compartment (V1; mL)	2620	(19)		2840	(8)
Distribution CL to compartment 2 (Q; mL h−1)	192	(62)		122	(24)
Volume of compartment 2 (V2; mL)	1070	(37)		821	(47)
IIV
IIV on CL (%)	45.1	(20)	[1]	37.6	(19)	[2]
IIV on V1 (%)	26.8	(62)	[20]	14.1	(95)	[37]
Correlation between CL and V1	66.4	(46)		45.6	(64)
Residual variability
Additive residual variability (IU dL−1)	0.66	(47.1)		0.65	(35)
Proportional residual variability (%)	13.8	(23)		13.7	(22)
Covariate relations
CL: allometric exponent	‐			1.65	(21)
V1: allometric exponent	‐			1.34	(19)
Model characteristics
Objective function value	−186.1			−217
Condition number	332			99

RSE: relative standard error. Shr.: shrinkage. IIV: interindividual variability. The individual values for the clearance parameters (CL, Q) and the volume of distribution parameters (V1, V2) from the final model are described by the following equations:

$$\begin{array}{c}{\mathrm{CL}}_{\mathrm{i}}=236\mathrm{x}{\left(\frac{\mathrm{IBW}}{{\mathrm{IBW}}_{\mathrm{med}}}\right)}^{1.65}\mathrm{x}{\mathrm{e}}^{{\mathrm{\eta }}_{\mathrm{CL},\mathrm{i}}}\\ \mathrm{V}{1}_{\mathrm{i}}=2840\mathrm{x}{\left(\frac{\mathrm{IBW}}{{\mathrm{IBW}}_{\mathrm{med}}}\right)}^{1.34}\mathrm{x}{\mathrm{e}}^{{\mathrm{\eta }}_{\mathrm{V}1,\mathrm{i}}}\\ {\mathrm{Q}}_{\mathrm{i}}=122\mathrm{x}{\left(\frac{\mathrm{IBW}}{{\mathrm{IBW}}_{\mathrm{med}}}\right)}^{1.65}\\ \mathrm{V}{2}_{\mathrm{i}}=821\mathrm{x}{\left(\frac{\mathrm{IBW}}{{\mathrm{IBW}}_{\mathrm{med}}}\right)}^{1.34}\end{array}$$

in which IBW is the value for the ideal body weight and IBW_med is the median of for the ideal body weight from the studied population.