TABLE 3.
Summary of the covariate relationship selection process
| Model and parameter | Covariate | OFV | AIC | dAIC | IIV on CL | IIV on V1 | Correlation between CL & V1 |
|---|---|---|---|---|---|---|---|
| Comparator model | −186.1 | −168.1 | 45.1 | 26.8 | 66.4 | ||
| Allometric scaling with fixed exponents | |||||||
| WT | −176.2 | −158.2 | 9.9 | 43.7 | 26.7 | 60.1 | |
| LBM | −208.1 | −190.1 | −22.1 | 39.5 | 16.4 | 46.7 | |
| IBW | −212.1 | −194.1 | −26.0 | 40.2 | 15.6 | 52.9 | |
| BMI | −160.9 | −142.9 | 25.2 | 47.7 | 34.1 | 69.3 | |
| ABW | −200.7 | −182.7 | −14.6 | 41.2 | 18.9 | 55.7 | |
| LBMc | −197.3 | −179.3 | −11.3 | 42.1 | 20.4 | 58.1 | |
| Allometric exponents estimated for CL & V1 | |||||||
| WT | −190.6 | −168.6 | −0.5 | 43.9 | 23.8 | 64.2 | |
| LBM | −212.6 | −190.6 | −22.5 | 37.3 | 15.7 | 46.2 | |
| IBW | −217.2 | −195.2 | −27.2 | 37.6 | 14.1 | 45.6 | |
| BMI | −186.8 | −164.8 | 3.3 | 44.8 | 26.7 | 66.1 | |
| ABW | −202.3 | −180.3 | −12.2 | 40.7 | 18.7 | 57.0 | |
| LBMc | −198.8 | −176.8 | −8.7 | 41.9 | 20.2 | 60.1 | |
OFV: objective function value; AIC: Akaike information criterion; dAIC: change in the AIC as compared to the AIC from the comparator model; IIV: interindividual variability; CL: clearance of the central compartment; V1: volume of distribution of the central compartment; WT: body weight; LBM: measured lean body mass; IBW: ideal body weight; BMI: body mass index; ABW: adjusted body weight; LBMc: calculated lean body mass.