REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
HA (for IPs)	BioLegend	Cat#MMS-101P
Actin	Santa Cruz	Cat#SC-1616-G
HA (for immunoblotting)	Cell Signaling	Cat#3724
Fasn	Cell Signaling	Cat#3189
Acot1	Abcam	Cat#ab100915
Rps2	Bethyl Labs	Cat#A303-794
Rpl36	Abcam	Cat#ab241584
Rps17	Abcam	Cat#ab128671
ChAT	Millipore	Cat#AB144P
NeuN	Millipore	Cat#MAB377
CD11b	BioLegend	Cat#MCA711
CD68	BioLegend	Cat#MCA1957
Synapsin	Cell Signaling	Cat#5297S
Tuj1	Sigma-Aldrich	Cat#T8578
MCP3 (CCL7)	Abcam	Cat#ab228979
Chemicals, peptides, and recombinant proteins
Protein G Magnetic beads	Fisher	Cat#S1430S
Donkey Serum	Jackson Immunoresearch	Cat#9624464
M.O.M. Blocking agent	Vector laboratories (Fisher)	Cat# MKB22131
Critical commercial assays
RNAScope Multiplex Fluorescent Reagent Kit v2	ACD	Cat#323100
SMART-Seq v4 Ultra Low Input RNA kit	Takara	Cat#R400752
SMARTer ThruPLEX DNA-Seq kit	Takara	Cat#R400675
Superscript III First-Strand Synthesis SuperMix	Invitrogen	Cat#18080400
Deposited data
Raw and Analyzed sequence data	This paper	GEO: GSE162028
Experimental models: Organisms/strains
Mouse: C57BL/6J	Jackson Laboratories	Stock#000664
Mouse: RiboTag: B6N.129-Rpl122tm1.1Psam/J	Jackson Laboratories	Stock#011029
Mouse: ChAT-IRES-Cre: B6;129S6-ChATtm(Cre)/Lowl/J	Jackson Laboratories	Stock#006410
Mouse: B6.SOD1-G93A: B6.Cg-Tg(SOD1∗G93A)1Gur/J	Jackson Laboratories	Stock#004435
Mouse: B6N.Cg-Tg(Prnp-TARDBP∗Q331K)103Dwc/J	Jackson Laboratories	Stock#017933
Mouse: B6.Cg-Tg(Prnp-TARDPBP∗A315T)95Balo/J	Jackson Laboratories	Stock#010700
Oligonucleotides
Primers for Real-time RT-PCR, see Table S1	This Paper	N/A