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. Author manuscript; available in PMC: 2021 Jul 1.
Published in final edited form as: Nature. 2021 Apr 14;592(7856):794–798. doi: 10.1038/s41586-021-03474-7

Extended Data Fig. 11 |. AMBRA1 regulates cyclin D protein stability and signalling through the RB pathway.

Extended Data Fig. 11 |

AMBRA1 limits CDK4/6 activity by mediating ubiquitylation and degradation of D-type cyclins as part of the CRL4 E3 ligase complex. Loss of AMBRA1 leads to accumulation of cyclin D protein and decreased sensitivity to CDK4/6 inhibitors, owing to sustained RB phosphorylation and therefore persistent cell cycle progression.