. 2021 Mar 22;114(1):175–184. doi: 10.1093/ajcn/nqab028

TABLE 2.

Risks of all-cause dementia under different meat types among APOE Ɛ4 noncarriers (n = 289,589) and carriers ( n = 115,537) respectively ¹

	Unadjusted models (n = 405,126)				Minimally adjusted models (n = 405,126)				Fully adjusted models (n = 405,126)
	HR	LCI	UCI	P	HR	LCI	UCI	P	HR	LCI	UCI	P
Risk of all-cause dementia
APOE Ɛ4 carriers vs. noncarriers	3.31	2.38	4.61	<0.001	3.59	2.48	5.19	<0.001	3.51	2.44	5.04	<0.001
Processed meat, 25 g/d
Stratified analysis
APOE Ɛ4 noncarriers	1.64	1.33	2.02	<0.001	1.36	1.09	1.70	0.007	1.46	1.15	1.84	0.002
APOE Ɛ4 carriers	1.18	0.96	1.45	0.112	1.09	0.88	1.36	0.436	1.47	1.16	1.85	0.001
P for interaction with APOE Ɛ4 allele				0.027				0.026				0.185
Unprocessed poultry, 25 g/d
Stratified analysis
APOE Ɛ4 noncarriers	0.84	0.74	0.96	0.009	0.92	0.79	1.07	0.261	0.93	0.79	1.09	0.379
APOE Ɛ4 carriers	0.82	0.73	0.93	0.002	0.89	0.77	1.03	0.111	0.94	0.81	1.09	0.435
P-interaction with APOE Ɛ4 allele				0.787				0.329				0.765
Unprocessed red meat, 50 g/d
Stratified analysis
APOE Ɛ4 noncarriers	1.31	1.04	1.66	0.023	0.94	0.75	1.19	0.633	0.93	0.72	1.21	0.594
APOE Ɛ4 carriers	0.89	0.72	1.11	0.311	0.64	0.51	0.80	<0.001	0.64	0.50	0.82	<0.001
P-interaction with APOE Ɛ4 allele				0.020				0.019				0.095
Total meat, 50 g/d
Stratified analysis
APOE Ɛ4 noncarriers	1.22	1.07	1.39	0.003	1.11	0.96	1.28	0.168	1.16	1.00	1.34	0.044
APOE Ɛ4 carriers	1.05	0.93	1.17	0.462	0.95	0.83	1.09	0.469	1.02	0.89	1.17	0.816
P-interaction with APOE Ɛ4 allele				0.091				0.062				0.054

Minimally adjusted models: Cox proportional-hazards regression adjusted for age, gender, ethnicity, education, socioeconomic status. Fully adjusted models: Cox proportional-hazards regression additionally adjusted for region, smoking status, physical activity, BMI, sleep duration, stroke history, family history of dementia, genetic kinship to other participants, dietary covariates including vegetables and fruits, total fish, tea and coffee, alcohol drinking, processed meat, unprocessed poultry, and unprocessed red meat were also mutually adjusted for. Mean daily intakes per increment calculated from the multiple 24-h dietary assessments were used as continuous variables in Cox models. APOE, apolipoprotein E; LCI, lower CI (95%); UCI, upper CI (95%).