TABLE 2.
Associations of vitamin B6 intake and other predictors with the 5 vitamin B6 markers in 3 nested case-control cohorts within the EPIC study (n = 4608)1
| Predictor | PLP | Hcy:Cys | Cysta:Cys | HKr | PAr |
|---|---|---|---|---|---|
| Minimally adjusted2 | |||||
| Vitamin B6 intake (doubling) | 1.62 (1.52, 1.73) | 0.84 (0.81, 0.87) | 0.91 (0.86, 0.97) | 0.88 (0.85, 0.91) | 1.01 (0.96, 1.06) |
| Fully adjusted3 | |||||
| Vitamin B6 intake (doubling) | 1.60 (1.50, 1.71) | 0.87 (0.84, 0.90) | 0.89 (0.84, 0.94) | 0.88 (0.85, 0.91) | 1.00 (0.95, 1.05) |
| Age (5 y) | 0.98 (0.97, 0.99) | 0.99 (0.99, 1.00) | 1.02 (1.01, 1.03) | 1.01 (1.00, 1.02) | 1.06 (1.05, 1.07) |
| BMI (5 kg/m2) | 0.93 (0.91 0.95) | 0.96 (0.95, 0.97) | 1.06 (1.04, 1.08) | 1.01 (1.00, 1.02) | 1.03 (1.01, 1.04) |
| Alcohol intake,4 (drinks/d) | 1.04 (1.03, 1.05) | 1.01 (1.01, 1.02) | 0.97 (0.96, 0.98) | 1.00 (0.99, 1.00) | 0.97 (0.97, 0.98) |
| Premenopausal women (vs. men) | 0.80 (0.74, 0.87) | 0.85 (0.82, 0.88) | 0.87 (0.82, 0.94) | 1.18 (1.13, 1.23) | 1.10 (1.04, 1.17) |
| Postmenopausal women (vs. men) | 0.99 (0.94, 1.03) | 0.88 (0.86, 0.90) | 0.91 (0.88, 0.95) | 1.13 (1.10, 1.16) | 1.01 (0.97, 1.04) |
| Smoker, former (vs. never) | 0.98 (0.94, 1.02) | 1.01 (0.99, 1.03) | 1.02 (0.99, 1.06) | 1.02 (1.00, 1.05) | 1.03 (1.00, 1.06) |
| Smoker, current (vs. never) | 0.80 (0.77, 0.84) | 1.08 (1.05, 1.10) | 0.98 (0.94, 1.01) | 1.06 (1.04, 1.08) | 1.11 (1.07, 1.15) |
Values are fold changes (95% credible intervals). Abbreviations: Cysta:Cys, cystathionine:cysteine; EPIC, European Prospective Investigation into Cancer and Nutrition; Hcy:Cys, homocysteine:cysteine; HKr, 3´-hydroxykynurenine ratio; PAr, 4-pyridoxic acid ratio; PLP, pyridoxal 5′-phosphate.
Adjusted only for total energy intake, case-control study, and case status; Bayesian regression with random intercepts for centers.
Adjusted for total energy intake, case-control study, case status, vitamin B6 intake, age, BMI, alcohol intake, sex and menopause status, and smoking status; Bayesian regression with random intercepts for centers.
12 g alcohol per drink.