TABLE 3.
Associations of PLP and other predictors with 3 functional vitamin B6 markers in 3 nested case-control cohorts within the EPIC study (n = 4608)1
| Predictor | Hcy:Cys | Cysta:Cys | HKr |
|---|---|---|---|
| Minimally adjusted2 | |||
| PLP (doubling) | 0.94 (0.94, 0.95) | 0.95 (0.93, 0.96) | 0.88 (0.87, 0.89) |
| Fully adjusted3 | |||
| PLP (doubling) | 0.94 (0.93, 0.95) | 0.95 (0.93, 0.96) | 0.88 (0.87, 0.89) |
| Age (5 y) | 0.99 (0.99, 1.00) | 1.02 (1.01, 1.03) | 1.00 (1.00, 1.01) |
| BMI (5 kg/m2) | 0.95 (0.95, 0.96) | 1.05 (1.03, 1.07) | 0.99 (0.98, 1.00) |
| Alcohol intake,4 (drinks/d) | 1.01 (1.01, 1.02) | 0.98 (0.97, 0.98) | 1.00 (1.00, 1.01) |
| Premenopausal women (vs. men) | 0.84 (0.81, 0.87) | 0.85 (0.79, 0.91) | 1.12 (1.08, 1.16) |
| Postmenopausal women (vs. men) | 0.89 (0.87, 0.91) | 0.90 (0.87, 0.94) | 1.12 (1.10, 1.15) |
| Smoker, former (vs. never) | 1.01 (0.99, 1.03) | 1.02 (0.98, 1.06) | 1.02 (1.00, 1.04) |
| Smoker, current (vs. never) | 1.06 (1.03, 1.08) | 0.96 (0.92, 1.00) | 1.01 (0.99, 1.04) |
1
Values are fold changes (95% credible intervals). Abbreviations: Cysta:Cys, cystathionine:cysteine; EPIC, European Prospective Investigation into Cancer and Nutrition; Hcy:Cys, homocysteine:cysteine; HKr, 3´-hydroxykynurenine ratio; PLP, pyridoxal 5′-phosphate.
2
Adjusted only for case-control study and case status; Bayesian regression with random intercepts for centers.
3
Adjusted for case-control study, case status, PLP, age, BMI, alcohol intake, sex and menopause status, and smoking status; Bayesian regression with random intercepts for centers.
4
12 g alcohol per drink.