TABLE 4.
Associations of PLP and other predictors with the 3 functional vitamin B6 markers, with Hcy:Cys and Cysta:Cys models additionally adjusted for circulating folate and cobalamin, and HKr model additionally adjusted for circulating riboflavin in 3 nested case-control cohorts, within the EPIC study (n = 4608)1
| Hcy:Cys | Cysta:Cys | HKr | |
|---|---|---|---|
| PLP (doubling) | 0.98 (0.98, 0.99) | 0.97 (0.96, 0.99) | 0.88 (0.87, 0.89) |
| Age (5 y) | 1.00 (0.99, 1.00) | 1.02 (1.01, 1.03) | 1.00 (1.00, 1.01) |
| BMI (5 kg/m2) | 0.95 (0.95, 0.96) | 1.05 (1.03, 1.07) | 0.99 (0.98, 1.00) |
| Alcohol intake,2 (drinks/d) | 1.02 (1.01, 1.02) | 0.98 (0.97, 0.98) | 1.00 (1.00, 1.01) |
| Premenopausal women (vs. men) | 0.87 (0.84, 0.90) | 0.87 (0.81, 0.93) | 1.12 (1.08, 1.16) |
| Postmenopausal women (vs. men) | 0.92 (0.91, 0.94) | 0.92 (0.89, 0.95) | 1.12 (1.10, 1.14) |
| Smoker, former (vs. never) | 1.01 (0.99, 1.03) | 1.02 (0.98, 1.06) | 1.02 (1.00, 1.04) |
| Smoker, current (vs. never) | 1.04 (1.02, 1.06) | 0.95 (0.91, 0.99) | 1.02 (0.99, 1.04) |
| Folate (doubling) | 0.86 (0.86, 0.87) | 0.91 (0.89, 0.93) | |
| Cobalamin (doubling) | 0.90 (0.89, 0.91) | 1.01 (0.98, 1.03) | |
| Riboflavin (doubling) | 1.01 (1.00, 1.01) |
Adjusted for case-control study, case status, PLP, age, BMI, alcohol intake, sex and menopause status, smoking status, and folate and cobalamin (Hcy:Cys and Cysta:Cys only) and riboflavin (HKr only); Bayesian regression with random intercepts for centers. Abbreviations: Cysta:Cys, cystathionine:cysteine; EPIC, European Prospective Investigation into Cancer and Nutrition; Hcy:Cys, homocysteine:cysteine; HKr, 3´-hydroxykynurenine ratio; PLP, pyridoxal 5′-phosphate.
12 g alcohol per drink.