TABLE 3.
Changes in BMD according to sex and PGS at 24 mo1
| Men | Women | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Tertile 1 | Tertile 2 | Tertile 3 | β (SE) | P | Tertile 1 | Tertile 2 | Tertile 3 | β (SE) | P | P-interaction | |
| Spine BMD, g/cm2 | 0.023 ± 0.021 | 0.023 ± 0.038 | 0.016 ± 0.041 | 0.002 (0.003) | 0.587 | −0.015 ± 0.033 | −0.010 ± 0.037 | −0.008 ± 0.030 | 0.003 (0.002) | 0.232 | 0.588 |
| Femoral hip BMD, g/cm2 | −0.020 ± 0.038 | −0.002 ± 0.027 | −0.016 ± 0.027 | 0.002 (0.003) | 0.567 | −0.027 ± 0.028 | −0.021 ± 0.028 | −0.012 ± 0.031 | 0.003 (0.002) | 0.057 | 0.165 |
| Whole-body BMD, g/cm2 | 0.011 ± 0.024 | 0.014 ± 0.029 | −0.002 ± 0.027 | −0.005 (0.002) | 0.041 | −0.010 ± 0.026 | −0.006 ± 0.023 | −0.002 ± 0.030 | 0.003 (0.002) | 0.092 | 0.008 |
Values are means ± SDs unless otherwise indicated. P values were adjusted for age, sex, race, diet group, BMI, physical activity, concurrent weight change, baseline dietary calcium intake, and baseline value for the respective outcome. General linear models (PROC GLM) were used for the analyses. BMD, bone mineral density; PGS, polygenic score.