Fig. 4.

Levels of main metabolites regulating the transsulfuration pathway in skeletal muscles of 17 weeks old control and mdx mice measured by NMR. (A) Scatter plots displaying the metabolite distribution of all classes of metabolites identified in quadriceps femoris muscle of control and mdx mice. (B–F) Left, graphs showing the levels of methionine, glycine, glutamate, glutathione and taurine detected in each control wt (n = 6) or dystrophic mouse (n = 6). Right, the bar graphs show the mean values ± SEM per group. Differences are considered statistically significant when p was ≤0.05. Double asterisk (**) and triple asterisk (***) denote a p-value of ≤0.01 and 0.001 vs wt mice.