Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jul 1;40:220. doi: 10.1186/s13046-021-02006-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 1 — APE1 expression associated with EMT and lymph node metastasis in cervical cancer patients. a Heatmap showing genes differentially expressed in cervical cancer with high expression (n = 4) and low expression of APE1 (n = 4). If the APE1 expression level in cancer tissues was higher than adjacent tissues, it was classified as the APE1 high expression group and if there was no difference, it was classified as the APE1 low expression group. b Gene set enrichment analysis (GSEA) of signaling pathways. GSEA was performed using transcriptome data from cervical cancer samples with high expression (n = 4) and low expression of APE1 (n = 4). If the mRNA expression level of APE1 in cancer tissues was higher than adjacent tissues, it was classified as the APE1 high expression group and if there was no difference, it was classified as the APE1 low expression group. c The expression levels of APE1 and E-cadherin were determined by immunohistochemistry (IHC) of 72 specimens of cervical cancer patients. The representative images are the standard scoring images used to evaluate the intensity of APE1 and E-cadherin staining. d The expression of APE1 and E-cadherin was negatively associated in cervical cancer patients. e A high expression level of APE1 was correlated with lymph node metastasis in cervical cancer patients. The difference was tested by the chi square test