Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jul 1;40:220. doi: 10.1186/s13046-021-02006-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 6 — APX3330 suppressed cervical cancer metastasis in vivo. a APX3330 treatment reduced the incidence of lymph node metastasis in lymph node metastasis models. Lymph node metastatic models were generated with GFP-expressing HeLa cells (HeLa-GFP). Fluorescence image: Tumor metastasis was monitored by fluorescence imaging at day 28 after cell injection; Anatomic image: Arrow indicates metastatic tumors; LN H&E: Hematoxylin and eosin (H&E) staining of lymph nodes (LNs); Tumor cells: Green color indicates GFP-expressing HeLa cells in lymph nodes. Blue, DAPI. Data were tested by the chi square test. b APX3330 treatment inhibited the incidence of liver metastasis in cervical cancer lymph node metastasis models. MRI image: Liver metastasis of tumor was detected by MRI at day 28 after cell injection; Anatomic image: The circle and arrow indicates metastatic tumor nodules on the surface of the liver; H&E: H&E staining of liver tissues; The circle and arrow indicates metastatic lesions in the liver. Tumor cells: Green indicates GFP-expressing HeLa cells in the liver. Blue, DAPI. Data were tested by the chi square test. c APX3330 treatment reduced cervical cancer abdominal cavity metastasis. Xenograft models were generated by intraperitoneal injection of HeLa-GFP cells into mice. Fluorescence image: Tumor metastasis was monitored by fluorescence imaging on day 21 after cell injection. Anatomic image: Arrow indicates metastatic tumors. H&E: Hematoxylin and eosin (H&E) staining shows metastatic lesions in the abdominal cavity. The circle and arrows indicate metastatic tumors. Data are presented as the mean ± SD and analyzed by unpaired t-tests. *, P < 0.05; **, P < 0.01; ***, P < 0.001. d APX3330 treatment inhibited cervical cancer cell lung metastasis. Lung metastatic models were generated by tail vein injection of HeLa-GFP cells into mice. Fluorescence image: Tumor metastasis was monitored by fluorescence imaging on day 28 after cell injection. Anatomic image: Arrow indicates metastatic tumor nodules on the lung surface. H&E: Hematoxylin and eosin (H&E) staining shows metastatic lesions in the lung. Arrows indicate the metastatic tumors. PBS, mice were treated with PBS by I.P. injection. **, P < 0.01; ***, P < 0.001