FIGURE 2.

Exacerbation of CHS is associated with skin Vγ4 + γ/δ T cells increment in Fabp3 ^−/− mice. (A, B) Frequency (left) and number (right) of CD3⁺ γ/δ TCR⁺, Vγ5⁺ and Vγ4⁺ γ/δ T cells in the inflamed (DNFB) ears (A) and normal (vehicle) ears (B) of WT and Fabp3 ^−/− mice at 24 h after challenge. (C) Frequency (left) and number (right) of IL‐17A⁺ Vγ4⁺ γ/δ T cells in the inflamed ears of WT and KO mice. (D, E) Ccr6 and Ccr2 (D) and Heb, Sox4, Sox13, Rorc, and Maf (E) mRNA expression of sorted dermal Vγ4⁺ γ/δ T cells in the inflamed and normal skin. Results are normalized to those of Gapdh and are presented relative to those of sorted dermal Vγ4⁺ γ/δ T cells in vehicle‐challenged WT mice. *P < .05 and ***P < .001 (Student's t test). Data are from one experiment representative of three independent experiments with similar results (A‐E) (mean ± SEM of three replicates (A‐E))