FIGURE 1.

Summary of DSM1‐resistant parasite clones used in this study. Wild‐type(WT1, Dd2)P. falciparumwas selected with DSM1 in two steps; the first step selected for low‐level (L) resistant parasites and the second step selected for moderate‐ (M) or high‐level (H) resistant parasites.Dhodhamplicon copy numbers (copies) were determined by qPCR; EC₅₀values are as follows: L1 (1 µM), L2 (1 µM), M1 (7 µM), H1 (62 µM), H2 (85 µM), H3 (36 µM), and H4 (49 µM). All values were previously reported in and clone names adapted from (Guler et al.,2013). Not shown: Wild type 2 (WT2) represents Hb3 (0.1 µM, no resistance)