Table 1.

Walking pattern across injection cycles in the comfortable barefoot category at Baseline and Week 12 (aboBoNT‐A doses combined)

	Double‐blind	Open‐label
	First injection	Second injection	Third injection	Fourth injection
Walking Velocity (m/s)	n = 220	n = 316	n = 253	n = 150
Baseline, * Mean (SD)	0.452 (0.22)	0.448 (0.22)	0.441 (0.22)	0.433 (0.20)
Mean (SD) at W12	0.521 (0.25)	0.528 (0.26)	0.529 (0.27)	0.521 (0.27)
Mean change (SD) at W12	0.069 (0.11)	0.081 (0.13)	0.088 (0.14)	0.088 (0.14)
P value (change from baseline)	<.0001	<.0001	<.0001	<.0001
Percentage change from baseline at W12 (95% CI)	19.68 (14.63, 24.73)	21.59 (17.41, 25.78)	25.08 (19.80, 30.35)	23.58 (17.41, 29.76)
Step Length (m/step)	n = 220	n = 316	n = 253	n = 150
Baseline, * Mean (SD)	0.345 (0.13)	0.350 (0.13)	0.346 (0.14)	0.347 (0.13)
Mean (SD) at W12	0.370 (0.14)	0.383 (0.14)	0.387 (0.15)	0.387 (0.16)
Mean change (SD) at W12	0.025 (0.06)	0.033 (0.07)	0.041 (0.07)	0.040 (0.08)
P value (change from baseline)	<.0001	<.0001	<.0001	<.0001
Percentage change from baseline at W12 (95% CI)	9.41 (6.64, 12.86)	11.77 (9.37, 14.17)	14.48 (11.44, 17.51)	13.80 (9.45, 18.15)
Cadence (steps/min)	n = 220	n = 316	n = 253	n = 150
Baseline, * Mean (SD)	76.7 (19.8)	75.2 (20.4)	74.9 (20.5)	73.7 (20.2)
Mean (SD) at W12	82.5 (20.8)	80.3 (21.8)	79.8 (21.6)	78.7 (22.1)
Mean change (SD) at W12	5.8 (11.8)	5.1 (12.7)	4.9 (13.3)	5.0 (12.3)
P value (change from baseline)	<.0001	<.0001	<.0001	<.0001
Percentage change from baseline at W12 (95% CI)	9.71 (6.21, 13.21)	8.39 (6.02, 10.76)	8.66 (5.89, 11.43)	8.43 (5.23, 11.62)

^*Baseline refers to baseline of the double‐blind study, prior to first injection of the patients entering the cycle. aboBoNT‐A, abobotulinumtoxinA; CI, confidence interval; SD, standard deviation; W12, Week 12.