Table 2.
Age-standardized participant characteristics according to recent period status of aspirin use in the pooled NHS and HPFSa
| Characteristics | Recent period duration of aspirin useb, y |
Recent period dose of aspirin usec, No. of 325-mg aspirin tablets/wk |
|||||
|---|---|---|---|---|---|---|---|
| 0 | 1-5 | 6-10 | <0.5 | 0.5 to <1.5 | 1.5 to <5 | ≥5 | |
| Remote period duration of aspirin used, mean (SD), y | 1.6 (3.0) | 3.4 (4.1) | 5.2 (4.8) | 1.9 (3.3) | 4.0 (4.3) | 4.5 (4.6) | 4.9 (4.9) |
| Recent period duration of aspirin usee, mean (SD), y | 0.0 (0.0) | 2.9 (1.0) | 8.2 (1.7) | 0.4 (1.5) | 5.7 (2.8) | 6.3 (2.9) | 6.0 (3.2) |
| Duration of nonaspirin NSAIDs use, mean (SD), y | 2.9 (3.5) | 3.3 (3.9) | 3.5 (4.1) | 3.1 (3.6) | 3.9 (4.5) | 3.5 (4.0) | 3.2 (3.5) |
| Remote period dose of aspirin usee (tablets/wk), mean (SD) | 1.3 (3.1) | 2.7 (4.2) | 4.5 (5.4) | 1.4 (3.1) | 2.2 (2.8) | 3.4 (3.7) | 7.0 (8.1) |
| Recent period dose of aspirin usec (tablets/wk), mean (SD) | 0.0 (0.0) | 3.0 (3.1) | 3.2 (2.7) | 0.0 (0.1) | 1.0 (0.3) | 2.8 (0.9) | 7.5 (3.5) |
| Dose of nonaspirin NSAIDs use (tablets/wk), mean (SD) | 1.8 (3.7) | 2.3 (3.9) | 2.6 (4.0) | 1.6 (3.7) | 2.3 (4.0) | 2.0 (4.0) | 2.3 (4.5) |
| Age, mean (SD), y | 65.7 (9.2) | 67.6 (9.2) | 69.9 (9.0) | 66.2 (9.3) | 71.2 (8.6) | 68.7 (9.1) | 67.1 (8.9) |
| White, % | 96.0 | 97.2 | 97.9 | 96.2 | 97.4 | 98.0 | 98.3 |
| BMI,f mean (SD), kg/m² | 26.2 (5.0) | 26.5 (5.0) | 26.5 (4.9) | 26.2 (5.1) | 26.3 (4.9) | 26.5 (5.1) | 27.0 (5.5) |
| Physical activity,g mean (SD), METs-h/wk | 19.8 (25.0) | 21.0 (26.0) | 22.6 (26.8) | 19.3 (24.7) | 22.6 (27.2) | 20.4 (25.3) | 19.0 (24.3) |
| Past smoking, % | 44.0 | 45.9 | 46.5 | 44.6 | 45.9 | 46.6 | 46.9 |
| Current smoking, % | 8.7 | 7.8 | 7.5 | 8.7 | 6.8 | 8.2 | 9.8 |
| Pack-years of smoking, mean (SD) | 12.2 (19.3) | 12.5 (19.2) | 12.8 (19.4) | 12.3 (19.4) | 11.4 (18.1) | 13.0 (19.6) | 15.0 (21.3) |
| Type 2 diabetes, % | 5.7 | 7.1 | 7.9 | 6.0 | 7.2 | 8.2 | 9.0 |
| Family history of CRC, % | 15.5 | 15.6 | 16.0 | 15.7 | 15.3 | 16.7 | 16.9 |
| Multivitamin use, % | 44.3 | 53.1 | 63.4 | 45.1 | 58.8 | 61.5 | 59.3 |
| Total folate intake, mean (SD), μg/d | 605 (300) | 652 (318) | 715 (339) | 605 (303) | 708 (330) | 675 (329) | 640 (321) |
| Total vitamin D, mean (SD), IU/d | 484 (379) | 519 (389) | 579 (430) | 493 (392) | 596 (458) | 561 (421) | 524 (393) |
| Total calcium intake, mean (SD), mg/d | 1200 (571) | 1238 (583) | 1299 (608) | 1221 (579) | 1329 (603) | 1317 (615) | 1276 (614) |
| AHEI, mean (SD) | 51.1 (10.4) | 51.4 (10.6) | 52.2 (11.1) | 51.4 (10.5) | 53.4 (11.1) | 51.7 (10.9) | 50.3 (10.6) |
| Alcohol, mean (SD), g/d | 5.5 (10.4) | 6.5 (11.2) | 7.8 (12.5) | 5.3 (10.0) | 6.9 (11.4) | 6.5 (11.2) | 6.0 (11.1) |
| Red or processed meat, mean (SD), servings/wk | 4.7 (3.4) | 4.9 (3.6) | 5.0 (3.8) | 4.6 (3.3) | 4.8 (3.5) | 4.7 (3.5) | 4.8 (3.6) |
| Total fiber, mean (SD), g/d, | 20.1 (6.0) | 20.6 (6.2) | 21.1 (6.5) | 19.9 (5.9) | 20.9 (6.3) | 20.3 (6.1) | 19.8 (6.0) |
| Total calorie intake, mean (SD), kcal/d | 1732 (534) | 1770 (563) | 1802 (588) | 1717 (524) | 1771 (569) | 1748 (560) | 1746 (555) |
Updated information throughout follow-up was used to calculate the mean (SD) for continuous variables and percentage for categorical variables. All variables are age standardized except age. AHEI = Alternate Healthy Eating Index score; BMI = body mass index; CRC = colorectal cancer; HPFS = Health Professionals Follow-up Study; METs = metabolic equivalent tasks; NHS = Nurses’ Health Study; NSAIDs = nonsteroidal anti-inflammatory drugs.
Recent period duration of aspirin use: duration of regular aspirin use during every specific subsequent 10-year period after the remote periods.
Recent period dose of aspirin use: cumulative average aspirin use during every specific subsequent 10-year period after the remote periods.
Remote period duration of aspirin use: duration of regular aspirin use during every specific remote period (>10 years before every follow-up period, ie, began from 1980 [NHS] and 1986 [HPFS] and then was extended by every 2-year subsequent interval at a time until 2002).
Remote period dose of aspirin use: cumulative average aspirin use during every specific remote period (>10 years before every follow-up period, ie, began from 1980 [NHS] and 1992 [HPFS] and then was extended by every 2-year subsequent interval at a time until 2002).
BMI was calculated as weight in kilograms divided by the square of height in meters.
Hours of metabolic equivalent tasks.