FIGURE 3.
(a) The effect of nociceptin (i.t.) and morphine (i.t.) and (b) the effect of systemic Ro65‐6570 (i.p.; NOP receptor agonist) and morphine (i.p.) on mechanical allodynia in 1.5 × 106·ml−1 of MRMT‐1/Luc2‐bearing animals in the von Frey test. (c) The effect of Ro65‐6570 (i.p.) is blocked by the NOP receptor antagonist J‐113397 (i.p.). All data are presented as mean ± SEM; n = 7 sham, n = 8 vehicle, n = 7 morphine, n = 8 nociceptin 1 μg, n = 8 nociceptin 3 μg, n = 6 nociceptin 10 μg in (a); n = 9 sham, n = 8 vehicle, n = 6 morphine, n = 7 Ro65‐6570 0.3 mg·kg−1, n = 6 Ro65‐6570 1.0 mg·kg−1, n = 5 Ro65‐6570 2.15 mg·kg−1 in (b); n = 9 vehicle, n = 8 Ro65‐6570, n = 8 J‐113397, n = 10 Ro65‐6570 + J‐113397 in (c); * P < .05 versus vehicle