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. 2020 Sep 23;10(5):471–485. doi: 10.1002/cpdd.869

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© 2020 Bristol Myers Squibb. Clinical Pharmacology in Drug Development published by Wiley Periodicals LLC on behalf of American College of Clinical Pharmacology

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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graphic file with name CPDD-10-471-g003.jpg — Effect of iberdomide on cytokine production ex vivo. (A) IL‐1α production in whole blood following lipopolysaccharide stimulation. (B) IL‐1β production in whole blood following lipopolysaccharide stimulation. (C) IL‐2 production in whole blood following anti‐CD3 stimulation. (D) IFN‐γ production in whole blood following anti‐CD3 stimulation. Data are mean percent of baseline ± SE. IL, interleukin; IFN, interferon; QD, once daily; SE, standard error. *P ≤ .05 relative to placebo; ⁺ P ≤ .05 relative to baseline.

graphic file with name CPDD-10-471-g005.jpg — Effect of iberdomide on cytokine production ex vivo. (A) IL‐1α production in whole blood following lipopolysaccharide stimulation. (B) IL‐1β production in whole blood following lipopolysaccharide stimulation. (C) IL‐2 production in whole blood following anti‐CD3 stimulation. (D) IFN‐γ production in whole blood following anti‐CD3 stimulation. Data are mean percent of baseline ± SE. IL, interleukin; IFN, interferon; QD, once daily; SE, standard error. *P ≤ .05 relative to placebo; ⁺ P ≤ .05 relative to baseline.