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. 2020 Sep 18;288(9):2784–2835. doi: 10.1111/febs.15531

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© 2020 The CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Fig. 4 — (A) Examples of SLC proteins transporting protons and bicarbonate ions (SLC4, SLC9, SLC26). SLC4A1 represents the subfamily of anion exchangers (AE), SLC4A4 represents the subfamily of electrogenic Na⁺/HCO₃ ⁻ cotransporters, while SLC4A7 represents the subfamily of electroneutral Na/HCO₃ ⁻ cotransporters. SLC9A1 serves as the prototypical Na⁺/H⁺ exchanger. SLC26A1 is an example of an SLC26 transporter that cotransports sulfate with Cl⁻. (B) Examples of SLC proteins transporting divalent ions (SLC8 and SLC24). SLC8A1 is shown as an example of a Ca²⁺/Na⁺ exchanger. SLC24A1 is shown as an example of K⁺‐dependent Na⁺/Ca²⁺ exchangers.