Table 2.
Intervention doses, blood loss and blood components administered to patients included in the study. Values are median (IQR [range]) or number (proportion).
| Intention to treat population | Per protocol | |||
|---|---|---|---|---|
|
PCC n = 25 |
FFP n = 25 ‡ |
PCC n = 21 |
FFP n = 21 ‡ |
|
| Dose of intervention | ||||
| Octaplex; IU* | 1000 (1000–1000 [0–1500]) | 1000 (1000–1000 [500–1500]) | ||
| FFP; units | 4 (4–5 [3–5]) | 4 (4–5 [3–5]] | ||
| Blood loss in chest drains at 24 h; ml | 525 (375–838 [180–2200)] | 575 (425–750 [300–1425]) | 475 (375–850 [275–2200]) | 575 (425–825 [325–1425]) |
| Blood components received at 24 h; units † | ||||
| Total | 4 (2–7 [1–16]) | 3 (1–6 [0–31]) | 4 (2–7 [1–16]) | 3 (1–6 [0–31]) |
| Red cells | 2 (1–3 [0–6]) | 2 (0–4 [0–12]) | 2 (1–3 [0–6]) | 2 (0–4 [0–12]) |
| FFP | 0 (0–0 [0–6]) | 0 (0–0 [0–10]) | 0 (0–0 [0–6]) | 0 (0–0 [0–10]) |
| Platelets | 1 (1–2 [0–4]) | 1 (0–2 [0–6]) | 1 (1–2 [0–4]) | 1 (0–2 [0–6]) |
| Cryoprecipitate | 1 (0–1 [0–3]) | 0 (0–2 [0–3]) | 0 (0–1 [0–3]) | 0 (0–2 [0–3]) |
| Blood components received at 7 days; units † | ||||
| Total | 6 (3–8 [1–16]) | 4 (2–7 [0–37]) | 5 (3–8 [1–16]) | 4 (2–7 [1–37]) |
| Red cells | 3 (2–4 [0–9]) | 2 (1–4 [0–16]) | 3 (2–4 [0–9]) | 2 (1–4 [0–16]) |
| FFP | 0 (0–0 [0–6]) | 0 (0–0 [0–12]) | 0 (0–0 [0–6]) | 0 (0–0 [0–12]) |
| Platelets | 1 (1–2 [0–5]) | 1 (0–2 [0–6]) | 1 (1–2 [0–5]) | 1 (0–2 [0–6]) |
| Cryoprecipitate | 1 (0–2 [0–3]) | 0 (0–2 [0–3]) | 0 (0–1 [0–3]) | 0 (0–2 [0–3]) |
| Blood components received at 30 days; units † | ||||
| Total | 6 (3–9 [1–21]) | 5 (2–7 [0–37]) | 5 (3–8 [1–21]) | 5 (2–7 [1–37]) |
| Red cells | 3 (2–5 [0–13]) | 2 (1–4 [0–16]) | 3 (2–4 [0–13]) | 2 (2–4 [0–16]) |
| FFP | 0 (0–0 [0–6]) | 0 (0–0 [0–12]) | 0 (0–0 [0–6]) | 0 (0–0 [0–12]) |
| Platelets | 1 (1–2 [0–5]) | 1 (0–2 [0–6]) | 1 (1–2 [0–5]) | 1 (0–2 [0–6]) |
| Cryoprecipitate | 1 (0–2 [0–3]) | 0 (0–2 [0–3]) | 0 (0–1 [0–3]) | 0 (0–2 [0–3]) |
| Haemostatic agents administered within 24 h of surgery | ||||
| Recombinant factor VIIa | 0 | 0 | 0 (0%) | 0 (0%) |
| Fibrinogen concentrate | 0 | 0 | 0 (0%) | 0 (0%) |
| Cell salvage | 17 (68%) | 18 (72%) | 14 (67%) | 15 (71%) |
| Time from intervention to chest closure; min | 80 (45–195 [0–610]) | 105 (45–173 [10–328]) | 75 (40–170 [0–250]) | 105 (45–173 [10–328]) |
PPC, prothrombin complex concentrate; FFP, fresh frozen plasma.
*
1 patient randomly allocated to PCC received 5 units of FFP.
†
Excludes FFP intervention.
‡
3 patients randomly allocated to FFP did not receive intervention.