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. 2021 Jun 30;19:69. doi: 10.1186/s12964-021-00751-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Transfer of RIP140-containing exosomes from neuron to macrophage. a Experimental diagram for (b) and (c). b Western blot analyses. GFP (representing GFP-RIP140) was detected in HT22 CM (top lane, donor cells) and receiving cell, Raw 264.7, lysate (bottom panel). c Left panel: Design of RIP140 editing to tag and knockout endogenous RIP140 of HT22 by Cre-recombinase. Right panel: qPCR of Arg-1 expression in Raw 264.7 cells after receiving HT22 CM. Data show 3 experimental results with Student’s t test (n = 3). *p ≤ 0.05. Error bars are represented as ± the Standard Error of the Mean (SE)