Table 3.
Candidate genes for wool traits and live weight in Merino sheep
| Trait | Gene | Chr | Start | End | Window rank | Specifically expressed tissue (P-valuea) | Specifically associated domain (P-valueb) |
|---|---|---|---|---|---|---|---|
| MFD | BNC1 | 18 | 22,758,417 | 22,784,473 | TOP3 | Skin (1.6E− 09) | Dermatology (2.0E− 15) |
| CVFD | ENDOV | 11 | 51,243,368 | 51,257,814 | TOP10 | Skin (0.03) | CNS (1.0E− 5) |
| CN | CDC6 | 11 | 40,114,668 | 40,125,179 | TOP1 | Embryonic (< 2.2E− 16) | Immune (2.1E− 09) |
| CN | RARA | 11 | 40,151,341 | 40,172,203 | TOP1 | Skin (0.04) | Immune (2.5E− 14) |
| CN | IGFBP4 | 11 | 40,250,021 | 40,260,382 | TOP1 | Liver (6E− 13) | Immune (8.4E− 12) |
| CN & MSL | GHR | 16 | 31,832,933 | 32,000,445 | TOP3 & TOP9 | Liver (< 2.2E− 16) | Metabolic (3.1E− 17) |
| MSL & GFW | PPP1R3D | 13 | 55,922,753 | 55,923,652 | TOP7 & TOP5 | Muscle (< 2.2E− 16) | Immune (0.002) |
| LW | CHRNB1 | 11 | 26,753,567 | 26,761,779 | TOP2 | Muscle (< 2.2E− 16) | Skeletal (8.8E− 39) |
| LW | ADSL | 3 | 215,669,356 | 215,684,701 | TOP3 | Muscle (< 3.5E− 14) | Metabolic (9.2E− 14) |
| LW | SPHK1 | 11 | 54,357,681 | 54,359,873 | TOP4 | Immune (< 2.2E− 16) | Immune (3.4E− 20) |
Chr, chromosome; MFD, mean fibre diameter; CVFD, coefficient of variation of the fibre diameter; CN, crimp number; MSL, mean staple length; GFW, greasy fleece weight; LW, live weight; CNS, central nervous system; GI tract, gastrointestinal tract
aThe P-values were computed by comparing the expression (TPM) of the given gene in the target tissues with that in the remaining tissues
bThe results were obtained from a phenome-wide association study (PheWAS), and the P-values were obtained from the top significant traits within the target domains