Table 2.
Characteristics of patients with COVID-19 categorized according to the composite endpoint of ICU admission/in-hospital death
| Non-ICU admitted/discharged alive n = 136 | ICU admitted/nonsurvivors n = 64 | P-value | |
|---|---|---|---|
| Age, y | 72 (16) | 77 (13) | 0.025 |
| Male sex, % | 52 | 59 | 0.342 |
| Body mass index, kg/m2 | 26.4 (4.2) | 25.6 (4.0) | 0.223 |
| Current smoking status, % | 18 | 17 | 0.908 |
| Hypertension, % | 61 | 62 | 0.842 |
| Type 2 diabetes, % | 15 | 31 | 0.010 |
| Previous cardiovascular event, % | 12 | 19 | 0.314 |
| Active cancer, % | 8 | 9 | 0.761 |
| Previous venous thromboembolism, % | 5 | 5 | 0.889 |
| Atrial fibrillation, % | 18 | 20 | 0.746 |
| Chronic obstructive pulmonary disease, % | 13 | 16 | 0.650 |
| Obesity, % | 31 | 25 | 0.428 |
| Charlson comorbidity index | 4 (2–6) | 5 (4–6) | 0.010 |
| Aangiotensin converting enzyme inhibitors, % | 26 | 26 | 0.901 |
| Angiotensin receptor blockers, % | 12 | 19 | 0.242 |
| Beta-blockers, % | 28 | 39 | 0.114 |
| Calcium channel blockers, % | 19 | 28 | 0.151 |
| Diuretics, % | 32 | 42 | 0.175 |
| Statins, % | 16 | 16 | 0.979 |
| Direct oral anticoagulants, % | 15 | 16 | 0.865 |
| Vitamin-K antagonists, % | 3 | 3 | 0.943 |
| Low molecular weight heparin, % | 19 | 25 | 0.341 |
| Antiplatelets, % | 18 | 33 | 0.024 |
| Insulin, % | 10 | 19 | 0.088 |
| Oral hypoglycemic agents, % | 9 | 17 | 0.084 |
| Systolic blood pressure, mmHg | 132 (20) | 130 (20) | 0.437 |
| Diastolic blood pressure, mmHg | 78 (11) | 75 (11) | 0.085 |
| Leukocytes, X 103/μL | 7.9 (5.4–10.7) | 8.4 (5.9–11.9) | 0.268 |
| Platelets, X 103/μL | 225 (162–283) | 204 (157–269) | 0.252 |
| D-dimer, ng/mL | 833 (551–1748) | 944 (482–1768) | 0.967 |
| C-reactive protein, mg/dL | 6.2 (3.2–11) | 7.4 (4.6–14.8) | 0.028 |
| Fasting glucose, mg/dL | 120 (103–152) | 127 (101–160) | 0.703 |
| Estimated glomerular filtration rate, mL/min | 74 (26) | 59 (26) | < 0.001 |
| Lactate dehydrogenase, UI/L | 3.4 (3.1–3.7) | 3.3 (3–3.6) | 0.113 |
| Albumin, g/dL | 279 (230–399) | 366 (296–467) | 0.003 |
| Arterial partial pressure of oxygen/fraction of inspiration oxygen | 260 (198–303) | 152 (133–271) | < 0.001 |
| CURB-65 score | 2 (1–2) | 2 (1–3) | < 0.001 |
| Vit-D, ng/mL | 11 (8–18) | 11 (6–18) | 0.839 |
ICU, intensive care unit; Vit-D, 25-hydroxyvitamin D.
Values are expressed as mean (standard deviation), median (25–75th percentile) or percentage.