Table 3.
Comparison of tract-based spatial statistics analysis of DTI and NODDI measures in participants
| Modality | Contrast | Significant voxels | Anatomical region | Mean (range) T-value | Peak MNI coordinates (X, Y, Z) |
|---|---|---|---|---|---|
| DTI | |||||
| FA | Autism < TD | 4229 | Bilateral ACR, SCR; Left ATR, CST, IFOF, UF, PCR; Forceps minor, genu, body, and splenium of CC | 1.88 (1.07−6.09) | 108, 120, 106 |
| MD | Autism > TD | 17,006 | Bilateral ATR, CST, IFOF, ILF, SLF, UF, ALIC, PLIC, retrolenticular part of IC, ACR, SCR, PCR, PTR, sagittal stratum, and SFOF; Left-CCG and CgH; Right-external capsule; Forceps major and minor, genu, body, and splenium of CC, and fornix | 1.61 (0.81–5.39) | 48, 107, 107 |
| RD | Autism > TD | 20,728 | Bilateral ATR, CST, CCG, IFOF, ILF, SLF, UF, ALIC, PLIC, retrolenticular part of IC, ACR, SCR, PCR, PTR, sagittal stratum, external capsule, and SFOF; Left-CgH; Right SLF temporal part; Forceps major and minor, genu, body, and splenium of CC, and fornix | 1.61 (0.81−6.27) | 144, 94, 102 |
| NODDI | |||||
| NDI | Autism < TD | 4110 | Bilateral IFOF, UF, and external capsule; Left ATR, ALIC, and ACR; Right CST, ILF, SLF, retrolenticular part of IC, SLF temporal part, SCR, PCR, and PTR; Forceps major and minor, genu and body of CC | 1.92 (1.07−4.84) | 109, 168, 94 |
| ISOVF | Autism > TD | 2472 | Left IFOF, ILF, SLF, UF, PLIC, retrolenticular part of IC, SCR, PCR, and PTR; Right-sagittal stratum; Forceps major, body, and splenium of CC | 1.77 (1.04 − 4.74) | 119, 101, 80 |
ACR, anterior corona radiata; ALIC, anterior limb of internal capsule; ATR, anterior thalamic, radiation; CCG, cingulum cingulate gyrus; CgH, cingulum hippocampus; CP, cerebral peduncle; CST, corticospinal tract; DTI, diffusion tensor imaging; FA, fractional anisotropy; IC, internal capsule; IFOF, inferior fronto-occipital fasciculus; ILF, inferior longitudinal fasciculus; ISOVF, isotropic volume fraction; MD, mean diffusivity; MNI, Montreal Neurological Institute; NDI, neurite density index; NODDI, neurite orientation dispersion and density imaging; PCR, posterior corona radiata; PLIC, posterior limb of internal capsule; PTR, posterior thalamic radiation; RD, radial diffusivity; SCR, superior corona radiata; SFOF, superior fronto-occipital fasciculus; SLF, superior longitudinal fasciculus; UF, uncinate fasciculus; TD, typically developing subjects