Table 1.
Clinical characteristics of healthy subjects and colorectal adenoma/cancer patients
| All (n = 676) | Symptomatic cohort (n = 241) | Asymptomatic cohort (n = 435) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Variables | Control (n = 265) | NAA (n = 86) | AA (n = 115) | CRC (n = 210) | P value † | Control (n = 50) | AA (n = 14) | CRC (n = 177) | P value † | Control (n = 215) | NAA (n = 86) | AA (n = 101) | CRC (n = 33) | P value † |
| Age | 58.1 ± 7.7 | 60.2 ± 5.0 | 61.1 ± 6.8 | 67.0 ± 11.3 | <0.0001 | 53.9 ± 13.2 | 68.9 ± 9.5 | 67.8 ± 11.1 | <0.0001 | 59.1 ± 5.3 | 60.2 ± 5.0 | 60.0 ± 5.5 | 63.0 ± 11.7 | 0.006 |
| Gender | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| Male | 110 (41.5%) | 49 (57.0%) | 66 (57.4%) | 124 (59.01%) | 0.0004 | 19 (38.0%) | 7 (50.0%) | 108 (61.0%) | 0.0139 | 91 (42.3%) | 49 (57.0%) | 59 (58.4%) | 16 (48.5%) | 0.0225 |
| Female | 155 (58.5%) | 37 (43.0%) | 49 (42.6%) | 86 (41.0%) | 31 (62.0%) | 7 (50.0%) | 69 (39.0%) | 124 (57.7%) | 37 (43.0%) | 42 (41.6%) | 17 (51.5%) | |||
| Location ‡ | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| Proximal | — | 22 (25.0%) | 22 (25.0%) | 54 (25.7%) | 5 (41.7%) | 47 (26.6%) | 17 (22.4%) | 7 (21.2%) | ||||||
| Distal | — | 48 (54.5%) | 48 (54.5%) | 156 (74.3%) | 7 (58.3%) | 130 (73.4%) | 41 (53.9%) | 26 (78.8%) | ||||||
| both | — | 18 (20.5%) | 18 (20.5%) | 0 (0%) | 0 (0%) | 0 (0%) | 18 (23.7%) | 0 (0%) | ||||||
| TNM stage § | — | — | — | — | — | — | — | — | — | — | — | — | — | |
| I | — | — | — | 31 (14.8%) | — | — | — | 24 (21.2%) | — | — | — | — | 7 (13.6%) | — |
| II | — | — | — | 68 (32.4%) | — | — | — | 64 (12.1%) | — | — | — | — | 4 (36.2%) | — |
| III | — | — | — | 73 (34.8%) | — | — | — | 57 (48.5%) | — | — | — | — | 16 (32.2%) | — |
| IV | — | — | — | 28 (13.3%) | — | — | — | 22 (18.2%) | — | — | — | — | 6 (12.4%) | — |
NAA, non‐advanced adenoma; AA, advanced adenoma; CRC, colorectal cancer; TNM, tumor‐node‐metastasis.
†
27 AA and 1 non‐advanced adenoma with location information missing.
‡
10 with unknown TNM staging.
§
Gender by chi‐square; age by one‐way ANOVA.