Figure 5.

Virus inactivation by S/D mixes containing novel compounds VI and VII. Matrices were spiked with the respective virus before addition of S/D mix (PS80, TNBP, compound VI/compound VII). Samples were drawn 1, 10, 30, and 60 min after S/D mix addition; viral loads of these samples were compared to a sample drawn before S/D mix addition to calculate the respective RF. A, B, Duplicate runs were performed at 17°C using a plasma‐derived model matrix and PRV; the final S/D mix concentrations were 5% of manufacturing. Asterisks indicate viral inactivation below the detection limit. C, D, Duplicate runs were performed at 1°C using a recombinant model matrix and Xenotropic murine leukemia virus (X‐MuLV); the final S/D mix concentrations were 10% of manufacturing. SD only shown if larger than the height of symbols). PRV, pseudorabies virus; RF, reduction factor; S/D, solvent/detergent; SD, standard deviation; TNBP, tri‐n‐butyl‐phosphate; TX‐100, Triton X‐100