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. 2021 Jun 16;12(16):5053–5065. doi: 10.7150/jca.57752

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miR-30a inhibited EMT and CSC phenotypes by targeting SOX4 through TGF- in breast cancer cells. (A) Western blot results of SOX4 and TGF-β/SMAD pathway related markers in cells with overexpression of miR-30a. (B) Western blot results of TGF-β/SMAD pathway related markers in cells with shSOX4. (C) Western blot results of TGF-β/SMAD pathway related markers in cells transfected with miR-30a or co-transfected with SOX4 lacking 3'UTR. (D) Heat map showed the relationship between miR-30a and markers of EMT, CSC, and canonical TGF-β/SMAD pathway. The color of the heat map represents the level of expression and the depth of the circle indicates the level of Spearman correlation coefficients between the expression of markers and miR-30a. ** P < 0.01, *** P < 0.001.